Strongest Differentiation
| Feature | Semaglutide | Tirzepatide | Retatrutide |
|---|---|---|---|
| GLP-1 effect | ✓ Yes | ✓ Yes | ✓ Yes |
| GIP effect | ✕ No | ✓ Yes | ✓ Yes |
| Glucagon effect | ✕ No | ✕ No | ✓ Yes |
| Appetite support | ✓ Yes | ✓ Yes | ✓ Yes |
| Blood sugar support | ✓ Yes | ✓ Yes | Studied |
| Weight-management research | Strong | Strong | Very strong early research |
| Legal / market status | Prescription product | Prescription product | Investigational |
| Best positioning | Established | Advanced dual-action | Next-generation research |
| Shop Now | Shop Now | Shop Now |